Giles is a founding partner of the architecture practice Assemble and an architect. He studied architecture at the University of Cambridge and the Royal College of Art and has taught architecture at the University of Westminster and lectured widely internationally. In 2016/17, Giles is co-leading the Design Think Tank New Knowledge with Anthony Engi-Meacock.

Assemble have delivered a diverse and award-winning body of work including art commissions for Art on the Underground, Nottingham Contemporary, the Venice Biennale, Argent, RIBA, Folkestone Triennial, V&A Dundee and many others. Their work has ranged from child-run adventure playgrounds in East Glasgow to open-access workshops in North East London, involving a number of scales, types and communities. Their work has been recognised by the Turner Prize in 2015 and in 2022 they were made Royal Academicians.